First evidence to show the toplogical change of DNAfrom B-DNA to Z-DNA Essay

First evidence to show the toplogical change of DNAfrom B-DNA to Z-DNA conformation in the hippocampus of Alzheimer's Brain - Essay Example The article claims that, there has been a discovery of altered DNA conformation for individuals suffering from AD (Suran et al 1). It is worthwhile giving credit to the article for clarity of objective. It has been able to differentiate and explain the differences in DNA configuration and conformation for both cases as well as providing evidence for intermediate cases. Additionally, the article was elaborate and illustrative enough whilst sticking to the objectives at the same time. For instance, the article explained the processes, which were used to come up with the evidence of B-DNA to Z-DNA conformation. On the other hand, the article may have failed to answer one important question. Truly, conformation happens but why. It only highlights the cause of disorders as degeneration of genetic material but does not go into elaborate detail on the process of degeneration. It can also be claimed that the article was overwhelmingly technical for persons outside the realms of medicine to understand anything. However, the main objective of the article was delivered in a scientifically acceptable